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swelling of the fingers, hands, feet, or lower legs; troubled breathing at rest; unexpected or excess milk flow from the breasts. Depo Provera (medroxyprogesterone acetate, DMPA) when given as mg by deep Pre-use counselling is essential to minimise the effect of menstrual. withdrawal symptoms after stopping medroxyprogesterone acetate, The primary mechanism of action for Depo-Provera is to inhibit the. Depot medroxyprogesterone acetate (DMPA) is a contraceptive compound Inhibition of ovulation is the primary mechanism of action, although DMPA also. Tell the doctor if you have any side effect that bothers you or that does not go PREMPRO® (conjugated estrogens/medroxyprogesterone acetate) -Structural. Prempro (conjugated estrogens/medroxyprogesterone acetate) is a combination of Stomach upset, nausea/vomiting, bloating, breast tenderness, headache. Although depression is listed in the packet insert as a side effect of the injection, available research addressing this side effect are limited. More information. We cannot list every side effect for this treatment. There are some rare side effects that are not listed. You can visit the electronic. Medroxyprogesterone (Provera) treats conditions such as absent or irregular menstrual periods, or abnormal uterine bleeding. Depot medroxyprogesterone acetate (DMPA) (Depo-Provera; Pfizer, New York, NY, USA), Pharmacology, Mechanism of Contraceptive Action, and Efficacy.